Prof. Hans-Georg Kräusslich has strongly contributed to HIV/AIDS research for more than 20 years.
He will deliver a talk titled, ‘HIV assembly and maturation: preparing a virus for entering a new cell’ under ‘Heidelberg Lecture Series’ on 12 March 2014 at 2:30pm at the auditorium of School of Life Sciences.
Prof. Hans-Georg Kräusslich has strongly contributed to HIV/AIDS research for more than 20 years, focusing on the assembly and structure of the viral particle. Since 2002, he is Director of Department for Infectious Diseases (former ‘The Hygiene-Institute’) at Heidelberg University.
As a postdoctoral fellow, he contributed to identifying the role of poliovirus proteases in host cell shutoff and was involved in the initial discovery of IRES-elements as translational control elements. During this period, he also established one of the first assays for HIV protease activity His group at DKFZ established the current concept for triggering and completing viral maturation through kinetic control of individual processing steps, and also contributed decisively to the development of HIV protease inhibitors as antiviral agents and their resistance mechanisms.
More recently, the Kräusslich group has identified a peptide that serves as the first described inhibitor of HIV assembly, and showed that it acts by binding to a hitherto unknown assembly interface. Together with collaborators from lipid mass spectrometry, he has determined the lipidome of HIV as the first comprehensive lipid analysis of any virus, showing that the HIV envelope is highly enriched in raft lipids and that altering lipid composition can affect virus infectivity.
At University of Hyderabad’s Auditorium at School of Life Sciences in the south campus, he would deliver a talk titled, ‘HIV assembly and maturation: preparing a virus for entering a new cell’ under ‘Heidelberg Lecture Series’ on 12 March 2014 at 2:30pm.